- RELEVANT PUBLICATIONS
Gómez-Castellano KM, Montes-Luna A, Carballo-Uicab G, Ramírez-Villedas FD, Elizarraras-Rodríguez L, Vázquez-Leiva SK, Rodríguez-Luna SD, González-González E, Pedraza-Escalona M, Holland B, Della-Cristina P, Rivera-Santiago C, Barrera-Saldaña HA, Pérez-Tapia SM, Almagro JC. Discovery and characterization of two anti-PD-1 antibodies with a unique binding mechanism to human PD-1. mAbs. Dec;17(1):2591461. 2025. ![]()
Carballo-Uicab G, Mellado-Sánchez G, González-González E, Salinas-Trujano J, Mendoza-Salazar I, López-Olvera K, Gómez-Castellano KM, Salazar IM, Torres-Flores JM, Chagoya-Cortés HE, Paz-De la Rosa G, Rojas-Martínez O, Lara Puente JH, Peralta-Sánchez GJ, Sarfati-Mizrahi D, Torres-Flores A, Sun W, Krammer F, García-Sastre A, Palese P, López-Macías C, Lozano-Dubernard B, Pérez-Tapia SM, Almagro JC. Addressing SARS-CoV-2 Evolution: Neutralization of Emerging Variants of Concern by the AVX/COVID-12 'Patria' Vaccine Based on HexaPro-S Ancestral Wuhan Spike or Its Updated BA.2.75.2 Version. Frontiers in Immunology. Front. Immunol. 18 May 2025. ![]()
Erasmus MF, Spector L, Perea-Schmittle K, Ferrara F, DiNiro R, Pettus C, Rodriguez Carnero LA, Li J, Cisneros A, Fanni A, Pohl TJ, Knight D, Cruz Z, Molina E, Wang W, Tessier P, Richardson C, Turner L, Bedinger D, Sormanni P, Fernandez-Quintero M, Ward A, Raybould M, Evers A, Bachas S, Ruffolo J, Nastri1 H, Ramesh K, Sørenson J, Croasdale-Wood R, Hijano O, Shahsavarian M, Qiu Y, Marcatili P, Vernet E, Akbar R, Friedenson S, Hartman T, Kurella VB, Malhotra A, Kumar S, Kidger P, Almagro JC, Furfine E, Stanton M, Villalba SD, Tomszak F, D’Angelo S, Bradbury ARM. AIntibody: An experimentally-validated in silico antibody discovery design challenge. Nature Biotech. 1-6. 2024. ![]()
Maciuba S, Bowden GD, Stratton HJ, Wisniewski K, Schteingart CD, Almagro JC, Valadon P, Lowitz J, Glaser SM, Lee G, Dolatyari M, Navratilova E, Porreca F, Rivière PJM. Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female pain. mAbs. 15: 2254676, 2023. ![]()
Pedraza-Escalona M, Guzmán-Bringas O, Arrieta-Oliva I, Gómez-Castellano K, Salinas-Trujano J, Torres-Flores J, Muñoz-Herrera JC, Camacho-Sandoval R, Contreras-Pineda P, Chacón-Salinas R, Pérez-Tapia SM, Almagro JC. Isolation and characterization of high affinity and highly stable anti-Chikungunya virus antibodies using ALTHEA Gold Libraries™. BMC Infectious Diseases. 21: 1121, 2021. ![]()
- BOOK CHAPTERS
- REVELANT PATENTS
Nastri HG, Stewart SM, Almagro JC, Zhou J, Buonpane RA, Wang H, Chen Y, Wang X, Carlsen PN, Li Y, Qi C, Wu L, Yao W, Zhu W, Huang T. Anti-Cd73 inhibitor and a2a/a2b adenosine receptor inhibitor combination therapy. Assignee: Incyte Corporation, Inc. Priority date: 12/30/2020. US Patent 12,060,433. Issued: 8/13/2024.
Henry R, Samarakoon T, Fishkin N, Zhu P, Pazolli E, Palacino J, Almagro JC. Anti-BCMA antibody-drug conjugates and methods of use. Assignee: Eisai R&D Management Co Ltd. Priority date: 06/04/2021. Publication date: US Patent number 12,043,670. Issued: 7/23/ 2024.
Nastri HG, Stewart SM, Almagro JC, Zhou J, Buonpane RA. Anti-cd73 antibodies and uses thereof. Assignee: Incyte Corporation, Inc. Priority date: 12/30/2020. US Patent 12,018,089. Issued: 6/25/2024.
Gulla SV, Huard C, Buhlmann JE, Almagro JC, Kodangattil SR, Greenberg SA, LaVallie ER, Bennett EM, Mosyak L, Hall JP, Coyle AJ. Interferon beta antibodies and uses thereof. Assignee: Pfizer Inc. Brigham and Women’s Hospital, Inc. Priority date: 12/9/2020. US Patent 11,858,986. Issued: 01/02/2024.
Chen J, Fransson J, Fursov N, Hamel D, Malia T, Obmolova G, Ort T, Rycyzyn M, Scully M, Sweet R, Teplyakov A, Wheeler J, Almagro JC. Neutralizing human anti-CD27 antibodies. Assignee: Janssen Biotech, Inc. Priority Date: 05/19/2020. US Patent: 11,732,050. Issued: 08/22/2023.
Manning PT, Puro R, Almagro JC. Therapeutic CD47 antibodies. Assignee: Arch Oncology, Inc. US Patent: 11,692,035. Issued: 07/04/2023.
Puro R, Hiebsch RR, Capoccia BJ., Andrejeva G, Almagro JC, Pereira DS. Therapeutic SIRP-alpha. antibodies. Assignee: Arch Oncology, Inc. US Patent: 11,202,828. Issued: 12/21/2021.
Almagro JC, DuBell W, Fransson J, Pardinas J, Raghunathan G. Method of treating osteoarthritis with human oncostatin M antibodies. Assignee: Janssen Biotech, Inc. Priority Date: 12/10/2018. US Patent: 10,941,197. Issued: 03/09/2021.
Manning PT, Puro R, Almagro JC, Karr RW. Therapeutic CD47 antibodies. Assignee: Arch Oncology, Inc. Priority Date: 02/08/2019. US Patent: 10,844,124. Issued: 11/24/2020.
Gulla SV, Huard C, Buhlmann, JE, Almagro JC, Kodangattil SR, Coyle AJ. Interferon Beta Antibodies and Uses Thereof. Assignee: PFIZER, INC. Priority Date: 04/29/2016. US Patent: 10,829,553. Issued: 11/10/2020.
Chen J, Fransson J, Fursov N, Hamel D, Malia T, Obmolova G, Ort T, Rycyzyn M, Scully M, Sweet R, Teplyakov A, Wheeler J, Almagro JC. Methods of inhibiting naive T-cell proliferation using anti-CD27 antibodies. JANSSEN BIOTECH, INC. US Patent: 10,689,453. Issued: 06/23/2020.
Chen J, Fransson J, Fursov N, Hamel D, Malia T, Obmolova G, Ort T, Rycyzyn M, Scully M, Sweet R, Teplyakov A, Wheeler J, Almagro JC. Methods of inhibiting T-cell mediated B-cell antibody production using anti-CD27 antibodies. JANSSEN BIOTECH, INC. US Patent: 10,301,392. Issued: 05/28/2019.
Manning P, Puro R, Almagro JC, Karr RW. Therapeutic CD47 Antibodies. US Patent: 10,239,945. Assignee: Arch Oncology, Inc. Issued: 03/26/2019.
Almagro JC, DuBell W, Fransson J, Pardinas J, Raghunathan G. Method of treating idiopathic pulmonary fibrosis by administering human oncostatin M antibodies. JANSSEN BIOTECH, INC. US Patent: 10,179,812. Issued: 01/15/2019.

